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KMID : 0861020100250040129
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Korea Journal of Herbology
2010 Volume.25 No. 4 p.129 ~ p.135
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The therapeutic effect of Achyranthis Radix on the collagen-induced arthritis in mice
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Kim Chang-Soo
Park Yong-Ki
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Abstract
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Objectives: The present study was undertaken to determine whether the water extract of Achyranthis Radix, which is the roots of Achyranthes japonica (Achyranthis Radix, AR), is efficacious against collagen-induced arthritis (CIA) in DBA/1J mice.
Methods: Mice were immunized with bovine type Ⅱ collagen and orally treated with AR-W (50 and 100 ㎎/㎏/bw) from days 21 to 42 after immunization. Arthritis was evaluated by arthritic score, histological examination of knee joint and serological markers such as TNF-α, PGE2 and anti-type II collagen (CⅡ)IgG.
Results: The results showed that comparing with untreated CIA mice, treated with AR-W significantly suppressed the clinical score and joint tissue pathological damages, reduced the serum levels of TNF-α, PGE2 and anti-CⅡ IgG in CIA-mice. These results suggest that AR-W can effectively alleviate inflammatory response on CIA, and anti-inflammatoy of AR-W can be attributed, at least partially, to the inhibition of inflamamtory mediators, PGE2 and TNF-α, in CIA.
Conclusions: This study suggests that AR-W has a therapeutic potential in inflammatory joint diseases such as rheumatoid arthritis.
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KEYWORD
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Achyranthes japonica, Achyranthis Radix, anti-arthritis, collagen-induced arthriis, inflammation
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